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Structural highlights

Function

TS1R3_HUMAN Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose (By similarity). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.^{[1] [2]}

References

1. ↑ Li X, Staszewski L, Xu H, Durick K, Zoller M, Adler E. Human receptors for sweet and umami taste. Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4692-6. PMID:11917125 doi:10.1073/pnas.072090199
2. ↑ Ariyasu T, Matsumoto S, Kyono F, Hanaya T, Arai S, Ikeda M, Kurimoto M. Taste receptor T1R3 is an essential molecule for the cellular recognition of the disaccharide trehalose. In Vitro Cell Dev Biol Anim. 2003 Jan-Feb;39(1-2):80-8. PMID:12892531 doi:<0080:TRTIAE>2.0.CO;2 10.1290/1543-706X(2003)039<0080:TRTIAE>2.0.CO;2