8gyq

Structural highlights

Function

PANX2_HUMAN Ion channel with a slight anion preference (PubMed:36973289). Also able to release ATP (PubMed:36869038). Plays a role in regulating neurogenesis and apoptosis in keratinocytes (By similarity).[UniProtKB:Q6IMP4]^{[1] [2]}

References

1. ↑ Zhang H, Wang S, Zhang Z, Hou M, Du C, Zhao Z, Vogel H, Li Z, Yan K, Zhang X, Lu J, Liang Y, Yuan S, Wang D, Zhang H. Cryo-EM structure of human heptameric pannexin 2 channel. Nat Commun. 2023 Mar 3;14(1):1118. PMID:36869038 doi:10.1038/s41467-023-36861-x
2. ↑ He Z, Zhao Y, Rau MJ, Fitzpatrick JAJ, Sah R, Hu H, Yuan P. Structural and functional analysis of human pannexin 2 channel. Nat Commun. 2023 Mar 27;14(1):1712. PMID:36973289 doi:10.1038/s41467-023-37413-z