1za3

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spinqualitylabelsall models 1za3, resolution 3.35Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

The crystal structure of the YSd1 Fab bound to DR5

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

Functional antibodies were obtained from a library of antigen-binding, sites generated by a binary code restricted to tyrosine and serine. An, antibody raised against human vascular endothelial growth factor, recognized the antigen with high affinity (K(D)=60 nM) and high, specificity in cell-based assays. The crystal structure of another antigen, binding fragment in complex with its antigen (human death receptor DR5), revealed the structural basis for this minimalist mode of molecular, recognition. Natural antigen-binding sites are enriched for tyrosine and, serine, and we show that these amino acid residues are intrinsically well, suited for molecular recognition. Furthermore, these results demonstrate, that molecular recognition can evolve from even the simplest chemical, diversity.

Disease

Known diseases associated with this structure: Squamous cell carcinoma, head and neck OMIM:[603612]

About this Structure

1ZA3 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Molecular recognition by a binary code., Fellouse FA, Li B, Compaan DM, Peden AA, Hymowitz SG, Sidhu SS, J Mol Biol. 2005 May 20;348(5):1153-62. Epub 2005 Apr 1. PMID:15854651

Page seeded by OCA on Mon Nov 12 20:31:42 2007