Structural highlights
Function
LDB7_YEAST Component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. Together with HTL1, NPL6, RSC3, RSC30 components, defines a fungal-specific module within the RSC complex that plays a role in many cellular functions including the maintenance of cell wall integrity. May be involved in the transfer of mannosylphosphate (MP) groups into N-linked oligosaccharides.[1] [2]
See Also
References
- ↑ Conde R, Pablo G, Cueva R, Larriba G. Screening for new yeast mutants affected in mannosylphosphorylation of cell wall mannoproteins. Yeast. 2003 Oct 30;20(14):1189-211. PMID:14587103 doi:http://dx.doi.org/10.1002/yea.1032
- ↑ Wilson B, Erdjument-Bromage H, Tempst P, Cairns BR. The RSC chromatin remodeling complex bears an essential fungal-specific protein module with broad functional roles. Genetics. 2006 Feb;172(2):795-809. Epub 2005 Oct 3. PMID:16204215 doi:http://dx.doi.org/genetics.105.047589
