8j87

Structural highlights

Function

TOP2_ASFB7 Type II topoisomerase (PubMed:25463606, PubMed:27060564). Processively relaxes supercoiled DNA (PubMed:27060564). Displays DNA-supercoiling activity only when associated with the viral histone-like protein (PubMed:28381576).^{[1] [2] [3]}

References

1. ↑ Coelho J, Martins C, Ferreira F, Leitão A. African swine fever virus ORF P1192R codes for a functional type II DNA topoisomerase. Virology. 2015 Jan 1;474:82-93. PMID:25463606 doi:10.1016/j.virol.2014.10.034
2. ↑ Coelho J, Ferreira F, Martins C, Leitão A. Functional characterization and inhibition of the type II DNA topoisomerase coded by African swine fever virus. Virology. 2016 Jun;493:209-16. PMID:27060564 doi:10.1016/j.virol.2016.03.023
3. ↑ Frouco G, Freitas FB, Coelho J, Leitão A, Martins C, Ferreira F. DNA-Binding Properties of African Swine Fever Virus pA104R, a Histone-Like Protein Involved in Viral Replication and Transcription. J Virol. 2017 May 26;91(12):e02498-16. PMID:28381576 doi:10.1128/JVI.02498-16