7x2u

Structural highlights

Disease

SL9A3_HUMAN Congenital sodium diarrhea;Cystic fibrosis. The disease is caused by variants affecting the gene represented in this entry.

Function

SL9A3_HUMAN Plasma membrane Na(+)/H(+) antiporter (PubMed:18829453, PubMed:26358773, PubMed:35613257). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry, playing a key role in salt and fluid absorption and pH homeostasis (By similarity). Major apical Na(+)/H(+) exchanger in kidney and intestine playing an important role in renal and intestine Na(+) absorption and blood pressure regulation (PubMed:24622516, PubMed:26358773).[UniProtKB:G3X939]^{[1] [2] [3] [4]}

References

1. ↑ He P, Zhang H, Yun CC. IRBIT, inositol 1,4,5-triphosphate (IP3) receptor-binding protein released with IP3, binds Na+/H+ exchanger NHE3 and activates NHE3 activity in response to calcium. J Biol Chem. 2008 Nov 28;283(48):33544-53. PMID:18829453 doi:10.1074/jbc.M805534200
2. ↑ Spencer AG, Labonte ED, Rosenbaum DP, Plato CF, Carreras CW, Leadbetter MR, Kozuka K, Kohler J, Koo-McCoy S, He L, Bell N, Tabora J, Joly KM, Navre M, Jacobs JW, Charmot D. Intestinal inhibition of the Na+/H+ exchanger 3 prevents cardiorenal damage in rats and inhibits Na+ uptake in humans. Sci Transl Med. 2014 Mar 12;6(227):227ra36. PMID:24622516 doi:10.1126/scitranslmed.3007790
3. ↑ Janecke AR, Heinz-Erian P, Yin J, Petersen BS, Franke A, Lechner S, Fuchs I, Melancon S, Uhlig HH, Travis S, Marinier E, Perisic V, Ristic N, Gerner P, Booth IW, Wedenoja S, Baumgartner N, Vodopiutz J, Frechette-Duval MC, De Lafollie J, Persad R, Warner N, Tse CM, Sud K, Zachos NC, Sarker R, Zhu X, Muise AM, Zimmer KP, Witt H, Zoller H, Donowitz M, Müller T. Reduced sodium/proton exchanger NHE3 activity causes congenital sodium diarrhea. Hum Mol Genet. 2015 Dec 1;24(23):6614-23. PMID:26358773 doi:10.1093/hmg/ddv367
4. ↑ Dong Y, Li H, Ilie A, Gao Y, Boucher A, Zhang XC, Orlowski J, Zhao Y. Structural basis of autoinhibition of the human NHE3-CHP1 complex. Sci Adv. 2022 May 27;8(21):eabn3925. PMID:35613257 doi:10.1126/sciadv.abn3925