8otx

Structural highlights

Function

SL9C1_STRPU Electroneutral sodium:proton antiporter that regulates intracellular pH of sperm along with capacitation and fertility. Activated in response to egg-derived chemoattractants, couples membrane voltage to sodium:proton exchange and transduces membrane hyperpolarization to cytoplasmic alkalization to cAMP signaling and ultimately to sperm motility.^{[1] [2] [3]}

References

1. ↑ Windler F, Bönigk W, Körschen HG, Grahn E, Strünker T, Seifert R, Kaupp UB. The solute carrier SLC9C1 is a Na(+)/H(+)-exchanger gated by an S4-type voltage-sensor and cyclic-nucleotide binding. Nat Commun. 2018 Jul 18;9(1):2809. PMID:30022052 doi:10.1038/s41467-018-05253-x
2. ↑ Yeo H, Mehta V, Gulati A, Drew D. Structure and electromechanical coupling of a voltage-gated Na(+)/H(+) exchanger. Nature. 2023 Nov;623(7985):193-201. PMID:37880360 doi:10.1038/s41586-023-06518-2
3. ↑ Kalienkova V, Peter MF, Rheinberger J, Paulino C. Structures of a sperm-specific solute carrier gated by voltage and cAMP. Nature. 2023 Nov;623(7985):202-209. PMID:37880361 doi:10.1038/s41586-023-06629-w