Structural highlights
Function
TIPJ_LAMBD Attaches the virion to the host receptor LamB, inducing viral DNA ejection. During tail assembly, initiates distal tail tip assembly by interacting with gpI, gpL and gpK. During virus entry to host cell, binds strongly to host LamB in an irreversible attachment. The binding induces structural changes in the tail leading to viral DNA injection through LamB trimeric pore.[1]
References
- ↑ Roessner CA, Ihler GM. Proteinase sensitivity of bacteriophage lambda tail proteins gpJ and pH in complexes with the lambda receptor. J Bacteriol. 1984 Jan;157(1):165-70. PMID:6228546 doi:10.1128/jb.157.1.165-170.1984
