9lhm

Structural highlights

Function

PACC1_HUMAN Proton-activated chloride channel that mediates import of chloride ion in response to extracellular acidic pH (PubMed:31023925, PubMed:31318332). Involved in acidosis-induced cell death by mediating chloride influx and subsequent cell swelling (PubMed:31023925, PubMed:31318332).^{[1] [2]}

References

1. ↑ Yang J, Chen J, Del Carmen Vitery M, Osei-Owusu J, Chu J, Yu H, Sun S, Qiu Z. PAC, an evolutionarily conserved membrane protein, is a proton-activated chloride channel. Science. 2019 Apr 26;364(6438):395-399. doi: 10.1126/science.aav9739. Epub 2019, Apr 25. PMID:31023925 doi:http://dx.doi.org/10.1126/science.aav9739
2. ↑ Ullrich F, Blin S, Lazarow K, Daubitz T, von Kries JP, Jentsch TJ. Identification of TMEM206 proteins as pore of PAORAC/ASOR acid-sensitive chloride channels. Elife. 2019 Jul 18;8. pii: 49187. doi: 10.7554/eLife.49187. PMID:31318332 doi:http://dx.doi.org/10.7554/eLife.49187