9nm3

Structural highlights

Function

FBF1_CAEEL RNA-binding protein that binds to the consensus sequence 5'-UGUGCCAUA-3' in mRNA 3'-UTRs (By similarity). Involved in the control of stem cells and sex determination in the C.elegans hermaphrodite germline (PubMed:9393998). May also play a role in the hermaphrodite germline proliferation and oogenesis (PubMed:15454534, PubMed:9393998). Binds specifically to the regulatory region of fem-3 3'-UTR and mediates the sperm/oocyte switch (PubMed:15454534, PubMed:9393998). Negatively regulates gld-3 expression, possibly by directly binding to two sites within the 3'-UTR of gld-3 isoform b (PubMed:15454534, PubMed:9393998). In association with the cye-1/cdk-2 complex, negatively regulates gld-1 expression in the distal germline cells of the mitotic zone (PubMed:21455289). By binding to the 3'-UTR, represses phosphatase lip-1 expression in the distal part of the germline mitotic zone (PubMed:16319922). Suppresses germline tumor formation by preventing the dedifferentiation of secondary spermatocytes (PubMed:22820175).[UniProtKB:Q09312]^{[1] [2] [3] [4] [5]}

References

1. ↑ Eckmann CR, Crittenden SL, Suh N, Kimble J. GLD-3 and control of the mitosis/meiosis decision in the germline of Caenorhabditis elegans. Genetics. 2004 Sep;168(1):147-60. PMID:15454534 doi:10.1534/genetics.104.029264
2. ↑ Lee MH, Hook B, Lamont LB, Wickens M, Kimble J. LIP-1 phosphatase controls the extent of germline proliferation in Caenorhabditis elegans. EMBO J. 2006 Jan 11;25(1):88-96. PMID:16319922 doi:10.1038/sj.emboj.7600901
3. ↑ Jeong J, Verheyden JM, Kimble J. Cyclin E and Cdk2 control GLD-1, the mitosis/meiosis decision, and germline stem cells in Caenorhabditis elegans. PLoS Genet. 2011 Mar;7(3):e1001348. PMID:21455289 doi:10.1371/journal.pgen.1001348
4. ↑ Cha DS, Datla US, Hollis SE, Kimble J, Lee MH. The Ras-ERK MAPK regulatory network controls dedifferentiation in Caenorhabditis elegans germline. Biochim Biophys Acta. 2012 Oct;1823(10):1847-55. PMID:22820175 doi:10.1016/j.bbamcr.2012.07.006
5. ↑ Zhang B, Gallegos M, Puoti A, Durkin E, Fields S, Kimble J, Wickens MP. A conserved RNA-binding protein that regulates sexual fates in the C. elegans hermaphrodite germ line. Nature. 1997 Dec 4;390(6659):477-84. PMID:9393998 doi:10.1038/37297