8ine

Structural highlights

Function

RL1D1_HUMAN Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage.^{[1] [2]}

See Also

• Ribosome 3D structures
• Ribosome biogenesis protein 3D structures

References

1. ↑ Ma L, Chang N, Guo S, Li Q, Zhang Z, Wang W, Tong T. CSIG inhibits PTEN translation in replicative senescence. Mol Cell Biol. 2008 Oct;28(20):6290-301. PMID:18678645 doi:10.1128/MCB.00142-08
2. ↑ Li N, Zhao G, Chen T, Xue L, Ma L, Niu J, Tong T. Nucleolar protein CSIG is required for p33ING1 function in UV-induced apoptosis. Cell Death Dis. 2012 Mar 15;3(3):e283. PMID:22419112 doi:10.1038/cddis.2012.22