9jyx

Structural highlights

Function

PITM1_HUMAN Catalyzes the transfer of phosphatidylinositol (PI) between membranes (PubMed:10531358, PubMed:22822086). Binds PI, phosphatidylcholine (PC) and phosphatidic acid (PA) with the binding affinity order of PI > PA > PC (PubMed:22822086). Regulates RHOA activity, and plays a role in cytoskeleton remodeling (PubMed:11909959). Necessary for normal completion of cytokinesis (PubMed:15125835). Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus (PubMed:15723057). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus (PubMed:15545272). Required for protein export from the endoplasmic reticulum and the Golgi (PubMed:15723057). Binds calcium ions (PubMed:10022914).^{[1] [2] [3] [4] [5] [6]}

References

1. ↑ Lev S, Hernandez J, Martinez R, Chen A, Plowman G, Schlessinger J. Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein. Mol Cell Biol. 1999 Mar;19(3):2278-88. PMID:10022914 doi:10.1128/MCB.19.3.2278
2. ↑ Fullwood Y, dos Santos M, Hsuan JJ. Cloning and characterization of a novel human phosphatidylinositol transfer protein, rdgBbeta. J Biol Chem. 1999 Oct 29;274(44):31553-8. PMID:10531358 doi:10.1074/jbc.274.44.31553
3. ↑ Tian D, Litvak V, Toledo-Rodriguez M, Carmon S, Lev S. Nir2, a novel regulator of cell morphogenesis. Mol Cell Biol. 2002 Apr;22(8):2650-62. PMID:11909959 doi:10.1128/MCB.22.8.2650-2662.2002
4. ↑ Amarilio R, Ramachandran S, Sabanay H, Lev S. Differential regulation of endoplasmic reticulum structure through VAP-Nir protein interaction. J Biol Chem. 2005 Feb 18;280(7):5934-44. PMID:15545272 doi:10.1074/jbc.M409566200
5. ↑ Litvak V, Dahan N, Ramachandran S, Sabanay H, Lev S. Maintenance of the diacylglycerol level in the Golgi apparatus by the Nir2 protein is critical for Golgi secretory function. Nat Cell Biol. 2005 Mar;7(3):225-34. PMID:15723057 doi:10.1038/ncb1221
6. ↑ Garner K, Hunt AN, Koster G, Somerharju P, Groves E, Li M, Raghu P, Holic R, Cockcroft S. Phosphatidylinositol transfer protein, cytoplasmic 1 (PITPNC1) binds and transfers phosphatidic acid. J Biol Chem. 2012 Sep 14;287(38):32263-76. PMID:22822086 doi:10.1074/jbc.M112.375840