Structural highlights
Function
MEGL_BREAU Catalyzes the alpha,gamma-elimination of L-methionine to produce methanethiol, 2-oxobutanoate and ammonia (PubMed:30940696, PubMed:9726878). May be responsible for the production of methanethiol associated with desirable Cheddar-type sulfur notes during cheese ripening (Probable). Is also able to catalyze the alpha,gamma-elimination of L-homocysteine and DL-selenomethionine, but has no activity toward L-cysteine, L-cystathionine, S-adenosyl-L-homocysteine and D-methionine (PubMed:30940696, PubMed:9726878).[1] [2] [3]
References
- ↑ Machover D, Rossi L, Hamelin J, Desterke C, Goldschmidt E, Chadefaux-Vekemans B, Bonnarme P, Briozzo P, Kopečný D, Pierigè F, Magnani M, Mollicone R, Haghighi-Rad F, Gaston-Mathé Y, Dairou J, Boucheix C, Saffroy R. Effects in Cancer Cells of the Recombinant l-Methionine Gamma-Lyase from Brevibacterium aurantiacum. Encapsulation in Human Erythrocytes for Sustained l-Methionine Elimination. J Pharmacol Exp Ther. 2019 Jun;369(3):489-502. PMID:30940696 doi:10.1124/jpet.119.256537
- ↑ Dias B, Weimer B. Purification and characterization of L-methionine gamma-lyase from brevibacterium linens BL2. Appl Environ Microbiol. 1998 Sep;64(9):3327-31. PMID:9726878 doi:10.1128/AEM.64.9.3327-3331.1998
- ↑ Dias B, Weimer B. Purification and characterization of L-methionine gamma-lyase from brevibacterium linens BL2. Appl Environ Microbiol. 1998 Sep;64(9):3327-31. PMID:9726878 doi:10.1128/AEM.64.9.3327-3331.1998
