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Publication Abstract from PubMed

Ordered protein-based assemblies are increasingly desirable for materials science, but the design of new materials remains challenging and requires considerable effort. Crystal lattice contact modulation enables rapid rational design of an assortment of structurally diverse constructs with crystalline order. Targeted disruption of crystal contacts and directional growth pre-biasing allows for restricting crystal lattice growth in selected directions, resulting in lower-dimension assemblies with parent crystal structural features. Two-dimensional crystals, one-dimensional fibres, flexible ribbons, and single-walled nanotubes based on tetratricopeptide repeat proteins were constructed from reengineered 3D crystal lattices. The large library of available crystal structures provides an abundance of engineering targets, promising to make crystal contact engineering a rapid and attractive approach for the design of ordered supramolecular protein assemblies.

Rational Crystal Contact Engineering for Programmable Self-Assembled Protein Architectures.,Liutkus M, Rojas AL, Cortajarena AL Angew Chem Int Ed Engl. 2025 Oct 12:e202516635. doi: 10.1002/anie.202516635. PMID:41077847^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.