9fbe

Structural highlights

Function

KDSAH_BACTN 3-keto-disaccharide hydrolase that preferentially hydrolyzes 3-keto-trehalose (3-dehydro-alpha,alpha-trehalose) (PubMed:33657378). Important for disaccharide utilization in the human gut (PubMed:33657378). Also shows hydrolysis activity with the glucosinolates glucoraphanin or glucobrassicin, but with much lower efficiency (PubMed:32084341).^{[1] [2]}

References

1. ↑ Liou CS, Sirk SJ, Diaz CAC, Klein AP, Fischer CR, Higginbottom SK, Erez A, Donia MS, Sonnenburg JL, Sattely ES. A Metabolic Pathway for Activation of Dietary Glucosinolates by a Human Gut Symbiont. Cell. 2020 Feb 20;180(4):717-728.e19. PMID:32084341 doi:10.1016/j.cell.2020.01.023
2. ↑ Liu H, Shiver AL, Price MN, Carlson HK, Trotter VV, Chen Y, Escalante V, Ray J, Hern KE, Petzold CJ, Turnbaugh PJ, Huang KC, Arkin AP, Deutschbauer AM. Functional genetics of human gut commensal Bacteroides thetaiotaomicron reveals metabolic requirements for growth across environments. Cell Rep. 2021 Mar 2;34(9):108789. PMID:33657378 doi:10.1016/j.celrep.2021.108789