Structural highlights
Function
APOA4_HUMAN May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.
Publication Abstract from PubMed
Cardiac amyloidosis (CA) occurs when misfolded proteins deposit as fibrils in the extracellular space of the heart. The fibrillogenic properties of apolipoprotein A-IV (ApoAIV) have been histologically observed and associated with CA pathogenesis. We report the structure of an ApoAIV amyloid from a patient's heart, which coexist amongst transthyretin (TTR) amyloids. These cases of undetected mixed CA highlight the importance of developing broad-spectrum anti-amyloid treatments to improve outcomes in patients.
Apolipoprotein A-IV fibrils: structural diagnosis of mixed cardiac amyloidosis.,Aibara S, Kassner A, Wong E, Klingel K, Papworth M, Althage M, Wang QD, Correia C, Milting H, de Oliveira TM Nat Commun. 2025 Oct 20;16(1):9276. doi: 10.1038/s41467-025-64902-0. PMID:41115976[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Aibara S, Kassner A, Wong E, Klingel K, Papworth M, Althage M, Wang QD, Correia C, Milting H, de Oliveira TM. Apolipoprotein A-IV fibrils: structural diagnosis of mixed cardiac amyloidosis. Nat Commun. 2025 Oct 20;16(1):9276. PMID:41115976 doi:10.1038/s41467-025-64902-0
