Structural highlights
Publication Abstract from PubMed
G-quadruplex structures formed by human telomeric sequences are highly sensitive to subtle sequence variations and local environment. While most structural studies have focused on sequences containing four uninterrupted G-tracts, the structural consequences of splitting a G-tract remain unexplored. Here, we present the NMR solution structure of a human telomeric sequence with the first G-tract split. The structure adopts an antiparallel topology with a disordered GTT segment at the 5'-end. This conformation is preferentially formed at a biologically relevant double-strand/single-strand DNA junction. These findings broaden our understanding of the structural diversity of human telomeric G-quadruplexes.
An antiparallel G-quadruplex structure with a 5'-end overhang forms predominantly at the human telomeric ds-ss DNA junction.,Avendano Avila C, Heddi B Chem Commun (Camb). 2025 Nov 7;61(90):17661-17664. doi: 10.1039/d5cc03633j. PMID:41099088[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Avendaño Avila C, Heddi B. An antiparallel G-quadruplex structure with a 5'-end overhang forms predominantly at the human telomeric ds-ss DNA junction. Chem Commun (Camb). 2025 Nov 7;61(90):17661-17664. PMID:41099088 doi:10.1039/d5cc03633j
