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2arw
From Proteopedia
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The solution structure of the membrane proximal cytokine receptor domain of the human interleukin-6 receptor
Overview
The members of the interleukin-6-type family of cytokines interact with, receptors that have a modular structure and are built of several, immunoglobulin-like and fibronectin type III-like domains. These receptors, have a characteristic cytokine receptor homology region consisting of two, fibronectin type III-like domains defined by a set of four conserved, cysteines and a tryptophan-serine-X-tryptophan-serine sequence motif. On, target cells, interleukin-6 (IL-6) initially binds to its cognate, alpha-receptor and subsequently to a homodimer of the signal transducer, receptor gp130. The IL-6 receptor (IL-6R) consists of three extracellular, domains. The N-terminal immunoglobulin-like domain is not involved in, ligand binding, whereas the third membrane-proximal fibronectin-like, domain (IL-6R-D3) accounts for more than 90% of the binding energy to, IL-6. Here, we present the solution structure of the IL-6R-D3 domain, solved by multidimensional heteronuclear NMR spectroscopy.
About this Structure
2ARW is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The solution structure of the membrane-proximal cytokine receptor domain of the human interleukin-6 receptor., Hecht O, Dingley AJ, Schwanter A, Ozbek S, Rose-John S, Grotzinger J, Biol Chem. 2006 Sep;387(9):1255-9. PMID:16972794
Page seeded by OCA on Mon Nov 12 20:54:06 2007
