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2b5i
From Proteopedia
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cytokine receptor complex
Contents |
Overview
Interleukin-2 (IL-2) is an immunoregulatory cytokine that acts through a, quaternary receptor signaling complex containing alpha (IL-2Ralpha), beta, (IL-2Rbeta), and common gamma chain (gc) receptors. In the structure of, the quaternary ectodomain complex as visualized at a resolution of 2.3, angstroms, the binding of IL-2Ralpha to IL-2 stabilizes a secondary, binding site for presentation to IL-2Rbeta. gammac is then recruited to, the composite surface formed by the IL-2/IL-2Rbeta complex. Consistent, with its role as a shared receptor for IL-4, IL-7, IL-9, IL-15, and IL-21, gammac forms degenerate contacts with IL-2. The structure of gammac, provides a rationale for loss-of-function mutations found in patients with, X-linked severe combined immunodeficiency diseases (X-SCID). This complex, structure provides a framework for other gammac-dependent, cytokine-receptor interactions and for the engineering of improved IL-2, therapeutics.
Disease
Known diseases associated with this structure: Combined immunodeficiency, X-linked, moderate OMIM:[308380], Diabetes mellitus, insulin-dependent, susceptibility to OMIM:[147730], Interleukin-2 receptor, alpha chain, deficiency of OMIM:[147730], Severe combined immunodeficiency due to IL2 deficiency OMIM:[147680], Severe combined immunodeficiency, X-linked OMIM:[308380]
About this Structure
2B5I is a Protein complex structure of sequences from Homo sapiens with NAG as ligand. Full crystallographic information is available from OCA.
Reference
Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors., Wang X, Rickert M, Garcia KC, Science. 2005 Nov 18;310(5751):1159-63. PMID:16293754
Page seeded by OCA on Mon Nov 12 20:59:01 2007
