2uym
From Proteopedia
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CRYSTAL STRUCTURE OF KSP IN COMPLEX WITH ADP AND THIOPHENE CONTAINING INHIBITOR 37
Overview
We have identified and synthesized a series of thiophene containing, inhibitors of kinesin spindle protein. SAR studies led to the synthesis of, 33, which was co-crystallized with KSP and determined to bind to an, allosteric pocket previously described for other known KSP inhibitors.
About this Structure
2UYM is a [Single protein] structure of sequence from [Homo sapiens] with MG, ADP and K03 as [ligands]. Full crystallographic information is available from [OCA].
Reference
Synthesis and SAR of thiophene containing kinesin spindle protein (KSP) inhibitors., Pinkerton AB, Lee TT, Hoffman TZ, Wang Y, Kahraman M, Cook TG, Severance D, Gahman TC, Noble SA, Shiau AK, Davis RL, Bioorg Med Chem Lett. 2007 Apr 29;. PMID:17498954
Page seeded by OCA on Mon Oct 29 18:45:46 2007
Categories: Homo sapiens | Single protein | Lee, T.T. | ADP | K03 | MG | Atp-binding | Cell cycle | Cell division | Coiled coil | Complex | Eg5 | Inhibitor | Kinesin spindle protein | Ksp | Microtubule | Mitosis | Motor protein | Nucleotide-binding | Phosphorylation | Thiophene
