2c6a

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2c6a

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SOLUTION STRUCTURE OF THE C4 ZINC-FINGER DOMAIN OF HDM2

Overview

HDM2 is a ubiquitin E3 ligase that is a key negative regulator of the, tumor suppressor p53. Here, we report the determination of the solution, structure of the C4 zinc finger domain of HDM2 using multidimensional NMR., The HDM2 C4 zinc finger domain has a fold consisting of a 3(10) helix, followed by four beta-strands, which shares significant structural, similarity to the zinc ribbon protein family. Family based sequence, analysis identified two putative binding sites, one of which resembles an, RNA binding motif.

About this Structure

2C6A is a Single protein structure of sequence from Homo sapiens with ZN as ligand. Full crystallographic information is available from OCA.

Reference

Solution structure of the C4 zinc finger domain of HDM2., Yu GW, Allen MD, Andreeva A, Fersht AR, Bycroft M, Protein Sci. 2006 Feb;15(2):384-9. Epub 2005 Dec 29. PMID:16385008

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