1yrk
From Proteopedia
The C2 Domain of PKC<delta> is a new Phospho-Tyrosine Binding Domain
Overview
In this issue of Cell, report that the C2 domain of the serine/threonine protein kinase Cdelta is a phosphotyrosine binding domain and present the crystal structure of this C2 domain bound to a peptide containing phosphotyrosine. Prior to this work, C2 domains were thought to bind only to phospholipids or to unphosphorylated proteins, and the SH2 and PTB domains were the only signaling domains known to recognize phosphotyrosine. This new role for the C2 domain links phosphotyrosine recognition directly to serine/threonine kinase activity and reveals an unexpected mechanism for crosstalk between distinct signaling pathways.
About this Structure
1YRK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
C2 can do it, too., Sondermann H, Kuriyan J, Cell. 2005 Apr 22;121(2):158-60. PMID:15851022 Page seeded by OCA on Sat May 3 16:41:35 2008
