2bmr

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spinqualitylabelsall models 2bmr, resolution 1.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

THE CRYSTAL STRUCTURE OF NITROBENZENE DIOXYGENASE IN COMPLEX WITH 3-NITROTOLUENE

Overview

Nitroaromatic compounds are used extensively in many industrial processes, and have been released into the environment where they are considered, environmental pollutants. Nitroaromatic compounds, in general, are, resistant to oxidative attack due to the electron-withdrawing nature of, the nitro groups and the stability of the benzene ring. However, the, bacterium Comamonas sp. strain JS765 can grow with nitrobenzene as a sole, source of carbon, nitrogen and energy. Biodegradation is initiated by the, nitrobenzene dioxygenase (NBDO) system. We have determined the structure, of NBDO, which has a hetero-hexameric structure similar to that of several, other Rieske non-heme iron dioxygenases. The catalytic subunit contains a, Rieske iron-sulfur center and an active-site mononuclear iron atom. ... [(full description)]

About this Structure

2BMR is a [Protein complex] structure of sequences from [Comamonas sp.] with FE, NI, FES, 3NT, EDO and EOH as [ligands]. Full crystallographic information is available from [OCA].

Reference

Structural insight into the dioxygenation of nitroarene compounds: the crystal structure of nitrobenzene dioxygenase., Friemann R, Ivkovic-Jensen MM, Lessner DJ, Yu CL, Gibson DT, Parales RE, Eklund H, Ramaswamy S, J Mol Biol. 2005 May 20;348(5):1139-51. Epub 2005 Apr 7. PMID:15854650

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