2com

From Proteopedia

proteopedia linkproteopedia link

spinqualitylabelsall models 2com Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

The solution structure of the SWIRM domain of human LSD1

Overview

SWIRM is an evolutionarily conserved domain involved in several, chromatin-modifying complexes. Recently, the LSD1 protein, which bears a, SWIRM domain, was found to be a demethylase for Lys4-methylated histone, H3. Here, we report a solution structure of the SWIRM domain of human, LSD1. It forms a compact fold composed of 6 alpha helices, in which a 20, amino acid long helix (alpha4) is surrounded by 5 other short helices. The, SWIRM domain structure could be divided into the N-terminal part, (alpha1-alpha3) and the C-terminal part (alpha4-alpha6), which are, connected to each other by a salt bridge. While the N-terminal part forms, a SWIRM-specific structure, the C-terminal part adopts a helix-turn-helix, (HTH)-related fold. We discuss a model in which the SWIRM domain acts as, an anchor site for a histone tail.

About this Structure

2COM is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Solution structure of the SWIRM domain of human histone demethylase LSD1., Tochio N, Umehara T, Koshiba S, Inoue M, Yabuki T, Aoki M, Seki E, Watanabe S, Tomo Y, Hanada M, Ikari M, Sato M, Terada T, Nagase T, Ohara O, Shirouzu M, Tanaka A, Kigawa T, Yokoyama S, Structure. 2006 Mar;14(3):457-68. PMID:16531230

Page seeded by OCA on Mon Nov 12 21:18:31 2007