2d1n
From Proteopedia
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Collagenase-3 (MMP-13) complexed to a hydroxamic acid inhibitor
Overview
Crystal structures of the catalytic domain of human stromelysin-1 (MMP-3), and collagenase-3 (MMP-13) with a hydroxamic acid inhibitor SM-25453 have, been solved at 2.01 and 2.37A resolutions, respectively. The results, revealed that the binding modes for this inhibitor to MMP-3 and -13 were, quite similar. However, subtle comparative differences were observed at, the bottom of S1' pockets, which were occupied with the guanidinomethyl, moiety of the inhibitor. A remarkable feature of the inhibitor was the, deep penetration of its long aliphatic chain into the S1' pocket and, exposure of the guanidinomethyl moiety to the solvent.
About this Structure
2D1N is a Single protein structure of sequence from Homo sapiens with ZN, CA and FA4 as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structures of the catalytic domain of human stromelysin-1 (MMP-3) and collagenase-3 (MMP-13) with a hydroxamic acid inhibitor SM-25453., Kohno T, Hochigai H, Yamashita E, Tsukihara T, Kanaoka M, Biochem Biophys Res Commun. 2006 May 26;344(1):315-22. Epub 2006 Mar 27. PMID:16603129
Page seeded by OCA on Mon Nov 12 21:25:27 2007
Categories: Homo sapiens | Single protein | Hochigai, H. | Kanaoka, M. | Kohno, T. | Tsukihara, T. | Yamashita, E. | CA | FA4 | ZN | Hydorolase metalloprotease
