This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2d9q
From Proteopedia
|
Crystal Structure of the Human GCSF-Receptor Signaling Complex
Overview
A crystal structure of the signaling complex between human granulocyte, colony-stimulating factor (GCSF) and a ligand binding region of GCSF, receptor (GCSF-R), has been determined to 2.8 A resolution. The, GCSF:GCSF-R complex formed a 2:2 stoichiometry by means of a cross-over, interaction between the Ig-like domains of GCSF-R and GCSF. The, conformation of the complex is quite different from that between human, GCSF and the cytokine receptor homologous domain of mouse GCSF-R, but, similar to that of the IL-6/gp130 signaling complex. The Ig-like domain, cross-over structure necessary for GCSF-R activation is consistent with, previously reported thermodynamic and mutational analyses.
About this Structure
2D9Q is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Homodimeric cross-over structure of the human granulocyte colony-stimulating factor (GCSF) receptor signaling complex., Tamada T, Honjo E, Maeda Y, Okamoto T, Ishibashi M, Tokunaga M, Kuroki R, Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3135-40. Epub 2006 Feb 21. PMID:16492764
Page seeded by OCA on Mon Nov 12 21:28:42 2007
