295d

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Template:STRUCTURE 295d

CRYSTAL AND SOLUTION STRUCTURES OF THE OLIGONUCLEOTIDE D(ATGCGCAT)2: A COMBINED X-RAY AND NMR STUDY


Overview

A combined crystal-structure determination and NMR analysis of the octanucleotide d(ATGCGCAT)2 is reported. The X-ray analysis shows that the structure is A-form duplex in crystal state. The NMR study shows that in solution this sequence is B-type. The conformational results from each technique are presented in detail. The implications of these findings in terms of conformational flexibility and ligand binding are discussed.

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal and solution structures of the oligonucleotide d(ATGCGCAT)2: a combined X-ray and NMR study., Clark GR, Brown DG, Sanderson MR, Chwalinski T, Neidle S, Veal JM, Jones RL, Wilson WD, Zon G, Garman E, et al., Nucleic Acids Res. 1990 Sep 25;18(18):5521-8. PMID:2216724 Page seeded by OCA on Sat May 3 18:26:05 2008

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