1w4r

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spinqualitylabelsall models 1w4r, resolution 1.83Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

STRUCTURE OF A TYPE II THYMIDINE KINASE WITH BOUND DTTP

Overview

The structure of human cytosolic thymidine kinase in complex with its, feedback inhibitor 2'-deoxythymidine-5'-triphosphate was determined. This, structure is the first representative of the type II thymidine kinases, found in several pathogens. The structure deviates strongly from the known, structures of type I thymidine kinases such as the Herpes simplex enzyme., It contains a zinc-binding domain with four cysteines complexing a, structural zinc ion. Interestingly, the backbone atoms of the type II, enzyme bind thymine via hydrogen-bonds, in contrast to type I, where side, chains are involved. This results in a specificity difference exploited, for antiviral therapy. The presented structure will foster the development, of new drugs and prodrugs for numerous therapeutic applications.

About this Structure

1W4R is a [Single protein] structure of sequence from [Homo sapiens] with ZN, TTP and DTU as [ligands]. Active as [[1]], with EC number [2.7.1.21]. Full crystallographic information is available from [OCA].

Reference

Structure of a type II thymidine kinase with bound dTTP., Birringer MS, Claus MT, Folkers G, Kloer DP, Schulz GE, Scapozza L, FEBS Lett. 2005 Feb 28;579(6):1376-82. PMID:15733844

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