2duv

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Image:2duv.gif

2duv, resolution 2.2Å

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Structure of CDK2 with a 3-hydroxychromones

Overview

A novel series of 3-hydroxychromones were prepared and found to be CDK, inhibitors. Isothiazolidine 1,1-dioxide analogues showed potent CDK1 and, CDK2 inhibitory activities and inhibited proliferation of EJ, HCT116, SW620, and MDAMB468 cancer cells.

About this Structure

2DUV is a Single protein structure of sequence from Homo sapiens with 371 as ligand. Active as Cyclin-dependent kinase, with EC number 2.7.11.22 Full crystallographic information is available from OCA.

Reference

3-Hydroxychromones as cyclin-dependent kinase inhibitors: Synthesis and biological evaluation., Lee J, Park T, Jeong S, Kim KH, Hong C, Bioorg Med Chem Lett. 2007 Mar 1;17(5):1284-7. Epub 2006 Dec 15. PMID:17178224

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