2alv
From Proteopedia
X-ray structural analysis of SARS coronavirus 3CL proteinase in complex with designed anti-viral inhibitors
Overview
Design, synthesis, and biological evaluation of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease (SARS-3CLpro) inhibitors for severe acute respiratory syndrome coronavirus (SARS-CoV) are described. These inhibitors exhibited antiviral activity against SARS-CoV in infected cells in the micromolar range. An X-ray crystal structure of our lead inhibitor (4) bound to SARS-3CLpro provided important drug-design templates for the design of small-molecule inhibitors.
About this Structure
2ALV is a Single protein structure of sequence from Human sars coronavirus. Full crystallographic information is available from OCA.
Reference
Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors., Ghosh AK, Xi K, Ratia K, Santarsiero BD, Fu W, Harcourt BH, Rota PA, Baker SC, Johnson ME, Mesecar AD, J Med Chem. 2005 Nov 3;48(22):6767-71. PMID:16250632 Page seeded by OCA on Sat May 3 19:12:05 2008
Categories: Human sars coronavirus | Single protein | Baker, S C. | Fu, W. | Ghosh, A K. | Harcourt, B H. | Johnson, M E. | Mesecar, A D. | Ratia, K. | Rota, P A. | Santarsiero, B D. | Xi, K. | 3c | 3cl | 3clpro | Anti-viral | Coronavirus | Inhibitor | Protease | Proteinase | Sar
