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2b2o

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Image:2b2o.gif

Template:STRUCTURE 2b2o

Crystal structure of native catalase-peroxidase KATG AT pH8.0


Overview

The catalase reaction of catalase-peroxidases involves catalase-specific features built into a peroxidase core. An arginine, 20 A from the active-site heme, acts as a molecular switch moving between two conformations, one that activates heme oxidation and one that activates oxoferryl heme reduction by H(2)O(2), facilitating the catalatic pathway in a peroxidase. The influence of the arginine is imparted to the heme through its association with or dissociation from a tyrosinate that modulates reactivity through a Met-Tyr-Trp crosslinked adduct and a pi electron interaction of the heme with the adduct Trp.

About this Structure

2B2O is a Single protein structure of sequence from Burkholderia pseudomallei. Full crystallographic information is available from OCA.

Reference

A molecular switch and electronic circuit modulate catalase activity in catalase-peroxidases., Carpena X, Wiseman B, Deemagarn T, Singh R, Switala J, Ivancich A, Fita I, Loewen PC, EMBO Rep. 2005 Dec;6(12):1156-62. PMID:16211084 Page seeded by OCA on Sat May 3 19:46:31 2008

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