This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2b4c
From Proteopedia
Crystal structure of HIV-1 JR-FL gp120 core protein containing the third variable region (V3) complexed with CD4 and the X5 antibody
Overview
The third variable region (V3) of the HIV-1 gp120 envelope glycoprotein is immunodominant and contains features essential for coreceptor binding. We determined the structure of V3 in the context of an HIV-1 gp120 core complexed to the CD4 receptor and to the X5 antibody at 3.5 angstrom resolution. Binding of gp120 to cell-surface CD4 would position V3 so that its coreceptor-binding tip protrudes 30 angstroms from the core toward the target cell membrane. The extended nature and antibody accessibility of V3 explain its immunodominance. Together, the results provide a structural rationale for the role of V3 in HIV entry and neutralization.
About this Structure
2B4C is a Protein complex structure of sequences from Homo sapiens and Human immunodeficiency virus 1. Full crystallographic information is available from OCA.
Reference
Structure of a V3-containing HIV-1 gp120 core., Huang CC, Tang M, Zhang MY, Majeed S, Montabana E, Stanfield RL, Dimitrov DS, Korber B, Sodroski J, Wilson IA, Wyatt R, Kwong PD, Science. 2005 Nov 11;310(5750):1025-8. PMID:16284180 Page seeded by OCA on Sat May 3 19:50:17 2008
Categories: Homo sapiens | Human immunodeficiency virus 1 | Protein complex | Dimitrov, D S. | Huang, C. | Korber, B. | Kwong, P D. | Majeed, S. | Montabana, E. | Sodroski, J. | Stanfield, R L. | Tang, M. | Wilson, I A. | Wyatt, R. | Zhang, M Y. | Cd4 induced antibody | Gp120 | Hiv-1 | Jrfl | V3 | X5
