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2f83

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Image:2f83.gif

2f83, resolution 2.87Å

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Crystal structure of a human coagulation factor

Contents

Overview

Factor XI (FXI), a coagulation protein essential to normal hemostasis, circulates as a disulfide-linked dimer. Here we report the full-length FXI, zymogen crystal structure, revealing that the protease and four apple, domains assemble into a unique 'cup and saucer' architecture. The, structure shows that the thrombin and platelet glycoprotein Ib binding, sites are remote within the monomer but lie in close proximity across the, dimer, suggesting a transactivation mechanism.

Disease

Known diseases associated with this structure: Factor XI deficiency, autosomal dominant OMIM:[264900], Factor XI deficiency, autosomal recessive OMIM:[264900]

About this Structure

2F83 is a Single protein structure of sequence from Homo sapiens with NAG and PT as ligands. Active as Coagulation factor XIa, with EC number 3.4.21.27 Full crystallographic information is available from OCA.

Reference

Crystal structure of the factor XI zymogen reveals a pathway for transactivation., Papagrigoriou E, McEwan PA, Walsh PN, Emsley J, Nat Struct Mol Biol. 2006 Jun;13(6):557-8. Epub 2006 May 14. PMID:16699514

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