2bsm
From Proteopedia
NOVEL, POTENT SMALL MOLECULE INHIBITORS OF THE MOLECULAR CHAPERONE HSP90 DISCOVERED THROUGH STRUCTURE-BASED DESIGN
Overview
The crystal structure of a previously reported screening hit 1 (CCT018159) bound to the N terminal domain of molecular chaperone Hsp90 has been used to design 5-amide analogues. These exhibit enhanced potency against the target in binding and functional assays with accompanying appropriate cellular pharmacodynamic changes. Compound 11 (VER-49009) compares favorably with the clinically evaluated 17-AAG.
About this Structure
2BSM is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design., Dymock BW, Barril X, Brough PA, Cansfield JE, Massey A, McDonald E, Hubbard RE, Surgenor A, Roughley SD, Webb P, Workman P, Wright L, Drysdale MJ, J Med Chem. 2005 Jun 30;48(13):4212-5. PMID:15974572 Page seeded by OCA on Sat May 3 20:44:43 2008
Categories: Homo sapiens | Single protein | Barril, X. | Brough, P A. | Cansfield, J E. | Drysdale, M J. | Dymock, B W. | Hubbard, R E. | Massey, A. | Mcdonald, E. | Roughley, S D. | Surgenor, A. | Webb, P. | Workman, P. | Wright, L. | Atp-binding | Atpase | Chaperone | Heat shock | Hsp90 | Pu3
