2fhw
From Proteopedia
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Solution structure of human relaxin-3
Overview
Relaxin-3 is the most recently discovered member of the relaxin family of, peptide hormones. In contrast to relaxin-1 and -2, whose main functions, are associated with pregnancy, relaxin-3 is involved in neuropeptide, signaling in the brain. Here, we report the solution structure of human, relaxin-3, the first structure of a relaxin family member to be solved by, NMR methods. Overall, relaxin-3 adopts an insulin-like fold, but the, structure differs crucially from the crystal structure of human relaxin-2, near the B-chain terminus. In particular, the B-chain C terminus folds, back, allowing Trp(B27) to interact with the hydrophobic core. This, interaction partly blocks the conserved RXXXRXXI motif identified as a, determinant for the interaction with the relaxin receptor LGR7 and may, account for the lower affinity of relaxin-3 relative to relaxin for this, receptor. This structural feature is likely important for the activation, of its endogenous receptor, GPCR135.
About this Structure
2FHW is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Solution structure and novel insights into the determinants of the receptor specificity of human relaxin-3., Rosengren KJ, Lin F, Bathgate RA, Tregear GW, Daly NL, Wade JD, Craik DJ, J Biol Chem. 2006 Mar 3;281(9):5845-51. Epub 2005 Dec 19. PMID:16365033
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