2fie

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Image:2fie.gif

2fie, resolution 2.81Å

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Structure of human liver FBPase complexed with potent benzoxazole allosteric inhibitors

Contents

Overview

A series of novel benzoxazole benzenesulfonamides was synthesized as, inhibitors of fructose-1,6-bisphosphatase (FBPase-1). Extensive SAR, studies led to a potent inhibitor, 53, with an IC(50) of 0.57microM., Compound 17 exhibited excellent bioavailability and a good pharmacokinetic, profile in rats.

Disease

Known disease associated with this structure: Fructose-bisphosphatase deficiency OMIM:[229700]

About this Structure

2FIE is a Single protein structure of sequence from Homo sapiens with A74 as ligand. Active as Fructose-bisphosphatase, with EC number 3.1.3.11 Full crystallographic information is available from OCA.

Reference

Benzoxazole benzenesulfonamides as allosteric inhibitors of fructose-1,6-bisphosphatase., Lai C, Gum RJ, Daly M, Fry EH, Hutchins C, Abad-Zapatero C, von Geldern TW, Bioorg Med Chem Lett. 2006 Apr 1;16(7):1807-10. Epub 2006 Jan 30. PMID:16446092

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