2flb

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Image:2flb.gif

2flb, resolution 1.95Å

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Discovery of a Novel Hydroxy Pyrazole Based Factor IXa Inhibitor

Contents

Overview

Synthesis and biological data of a novel selective and efficacious factor, IXa inhibitor are described along with its crystal structure in factor, VIIa.

Disease

Known diseases associated with this structure: Esophageal squamous cell carcinoma OMIM:[606551], Factor VII deficiency OMIM:[227500], Myocardial infarction, decreased susceptibility to OMIM:[227500]

About this Structure

2FLB is a Protein complex structure of sequences from Homo sapiens with 6NH as ligand. Full crystallographic information is available from OCA.

Reference

Discovery of novel hydroxy pyrazole based factor IXa inhibitor., Vijaykumar D, Sprengeler PA, Shaghafi M, Spencer JR, Katz BA, Yu C, Rai R, Young WB, Schultz B, Janc J, Bioorg Med Chem Lett. 2006 May 15;16(10):2796-9. Epub 2006 Feb 17. PMID:16487703

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