2fxk

From Proteopedia

Revision as of 20:05, 12 November 2007 by OCA (Talk | contribs)
(diff) ←Older revision | Current revision (diff) | Newer revision→ (diff)
Jump to: navigation, search
Image:2fxk.gif

2fxk, resolution 2.54Å

Drag the structure with the mouse to rotate

Crystal structure of the macro-domain of human core histone variant macroH2A1.1 (form A)

Overview

Histone macroH2A is a hallmark of mammalian heterochromatin. Here we show, that human macroH2A1.1 binds the SirT1-metabolite O-acetyl-ADP-ribose, (OAADPR) through its macro domain. The 1.6-A crystal structure and mutants, reveal how the metabolite is recognized. Mutually exclusive exon use in, the gene H2AFY produces macroH2A1.2, whose tissue distribution differs., MacroH2A1.2 shows only subtle structural changes but cannot bind, nucleotides. Alternative splicing may thus regulate the binding of, nicotinamide adenine dinucleotide (NAD) metabolites to chromatin.

About this Structure

2FXK is a Single protein structure of sequence from Homo sapiens. This structure superseeds the now removed PDB entry 1ZQ0. Full crystallographic information is available from OCA.

Reference

Splicing regulates NAD metabolite binding to histone macroH2A., Kustatscher G, Hothorn M, Pugieux C, Scheffzek K, Ladurner AG, Nat Struct Mol Biol. 2005 Jul;12(7):624-5. Epub 2005 Jun 19. PMID:15965484

Page seeded by OCA on Mon Nov 12 22:11:28 2007

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2fxk"
Personal tools