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2hci

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Revision as of 20:23, 12 November 2007 by OCA (Talk | contribs)
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Image:2hci.gif

2hci, resolution 1.81Å

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Structure of Human Mip-3a Chemokine

Overview

The structure of the human macrophage inflammatory protein-3alpha, (MIP-3alpha) has been determined at 1.81 angstroms resolution by X-ray, crystallography. The dimer crystallized in the tetragonal space group I4, with unit-cell parameters a = b = 83.99, c = 57.20 angstroms. The crystals, exhibit two molecules in the asymmetric unit. The structure was solved by, the molecular-replacement method and the model was refined to a, conventional R value of 20.6% (R(free) = 25.7%). MIP-3alpha possesses the, same monomeric structure as previously described for other chemokines., However, in addition to limited structural changes in the beta1-beta2, hairpin of monomer B, the electron density is fully defined for a few, extra residues at the N- and C-termini of monomer A and the C-terminus of, monomer B compared with MIP-3alpha in space group P6(1). As the N-terminal, and loop regions have been shown to be critical for receptor binding and, signaling, this additional structural information may help in determining, the basis of the CCR6 selectivity of MIP-3alpha.

About this Structure

2HCI is a Single protein structure of sequence from [1] with SO4, SO3 and PEG as ligands. Full crystallographic information is available from OCA.

Reference

Structure of human MIP-3alpha chemokine., Malik ZA, Tack BF, Acta Crystallograph Sect F Struct Biol Cryst Commun. 2006 Jul 1;62(Pt, 7):631-4. Epub 2006 Jun 30. PMID:16820679

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