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2hhn

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Revision as of 20:26, 12 November 2007 by OCA (Talk | contribs)
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Image:2hhn.gif

2hhn, resolution 1.55Å

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Cathepsin S in complex with non covalent arylaminoethyl amide.

Overview

The synthesis and structure-activity relationship of a series of, arylaminoethyl amide cathepsin S inhibitors are reported. Optimization of, P3 and P2 groups to improve overall physicochemical properties resulted in, significant improvements in oral bioavailability over early lead, compounds. An X-ray structure of compound 37 bound to the active site of, cathepsin S is also reported.

About this Structure

2HHN is a Single protein structure of sequence from Homo sapiens with SO4 and GNQ as ligands. Active as Cathepsin S, with EC number 3.4.22.27 Full crystallographic information is available from OCA.

Reference

Synthesis and SAR of arylaminoethyl amides as noncovalent inhibitors of cathepsin S: P3 cyclic ethers., Tully DC, Liu H, Chatterjee AK, Alper PB, Epple R, Williams JA, Roberts MJ, Woodmansee DH, Masick BT, Tumanut C, Li J, Spraggon G, Hornsby M, Chang J, Tuntland T, Hollenbeck T, Gordon P, Harris JL, Karanewsky DS, Bioorg Med Chem Lett. 2006 Oct 1;16(19):5112-7. Epub 2006 Jul 28. PMID:16876402

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