2hm1

From Proteopedia

Revision as of 20:27, 12 November 2007 by OCA (Talk | contribs)
(diff) ←Older revision | Current revision (diff) | Newer revision→ (diff)
Jump to: navigation, search
Image:2hm1.gif

2hm1, resolution 2.200Å

Drag the structure with the mouse to rotate

Crystal Structure of human beta-secretase (BACE) in the presence of an inhibitor (2)

Overview

We describe an optimized series of acyclic hydroxyethylamine transition, state isosteres of beta-secretase that incorporates a variety of P(2) side, chains that yield potent inhibitors with excellent cellular activity. A, 2.2A crystal structure of compound 13 is shown.

About this Structure

2HM1 is a Single protein structure of sequence from Homo sapiens with LIQ as ligand. Active as Memapsin 2, with EC number 3.4.23.46 Full crystallographic information is available from OCA.

Reference

Design of potent inhibitors of human beta-secretase. Part 2., Freskos JN, Fobian YM, Benson TE, Moon JB, Bienkowski MJ, Brown DL, Emmons TL, Heintz R, Laborde A, McDonald JJ, Mischke BV, Molyneaux JM, Mullins PB, Bryan Prince D, Paddock DJ, Tomasselli AG, Winterrowd G, Bioorg Med Chem Lett. 2007 Jan 1;17(1):78-81. Epub 2006 Oct 4. PMID:17049233

Page seeded by OCA on Mon Nov 12 22:34:07 2007

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2hm1"
Personal tools