2hnx
From Proteopedia
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Crystal Structure of aP2
Overview
Human adipocyte lipid-binding protein (aP2) belongs to a family of, intracellular lipid-binding proteins involved in the transport and storage, of lipids. Here, the crystal structure of human aP2 with a bound palmitate, is described at 1.5 A resolution. Unlike the known crystal structure of, murine aP2 in complex with palmitate, this structure shows that the fatty, acid is in a folded conformation and that the loop containing Phe57 acts, as a lid to regulate ligand binding by excluding solvent exposure to the, central binding cavity.
About this Structure
2HNX is a Single protein structure of sequence from Homo sapiens with PO4, PLM and ACY as ligands. Full crystallographic information is available from OCA.
Reference
Expression, purification, crystallization and structure of human adipocyte lipid-binding protein (aP2)., Marr E, Tardie M, Carty M, Brown Phillips T, Wang IK, Soeller W, Qiu X, Karam G, Acta Crystallograph Sect F Struct Biol Cryst Commun. 2006 Nov 1;62(Pt, 11):1058-60. Epub 2006 Oct 25. PMID:17077479
Page seeded by OCA on Mon Nov 12 22:34:31 2007
Categories: Homo sapiens | Single protein | Carty, M. | Karam, G. | Marr, E. | Phillips, T.Brown. | Qiu, X. | Tardie, M. | ACY | PLM | PO4 | Fatty acid binding protein
