2huy

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Image:2huy.gif

2huy, resolution 1.700Å

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X-ray crystal structure of the complex between the Grb2-SH2 domain and a flexible ligand, fpYVN.

Disease

Known diseases associated with this structure: Central hypoventilation syndrome, congenital OMIM:[100790], Haddad syndrome OMIM:[100790]

About this Structure

2HUY is a Single protein structure of sequence from Homo sapiens with YVN and FMT as ligands. Full crystallographic information is available from OCA.

Reference

Ligand preorganization may be accompanied by entropic penalties in protein-ligand interactions., Benfield AP, Teresk MG, Plake HR, DeLorbe JE, Millspaugh LE, Martin SF, Angew Chem Int Ed Engl. 2006 Oct 20;45(41):6830-5. PMID:17001728

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