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2f83

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Template:STRUCTURE 2f83

Crystal structure of a human coagulation factor


Overview

Factor XI (FXI), a coagulation protein essential to normal hemostasis, circulates as a disulfide-linked dimer. Here we report the full-length FXI zymogen crystal structure, revealing that the protease and four apple domains assemble into a unique 'cup and saucer' architecture. The structure shows that the thrombin and platelet glycoprotein Ib binding sites are remote within the monomer but lie in close proximity across the dimer, suggesting a transactivation mechanism.

About this Structure

2F83 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the factor XI zymogen reveals a pathway for transactivation., Papagrigoriou E, McEwan PA, Walsh PN, Emsley J, Nat Struct Mol Biol. 2006 Jun;13(6):557-8. Epub 2006 May 14. PMID:16699514 Page seeded by OCA on Sun May 4 03:34:31 2008

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