2nll

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Image:2nll.gif

2nll, resolution 1.900Å

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RETINOID X RECEPTOR-THYROID HORMONE RECEPTOR DNA-BINDING DOMAIN HETERODIMER BOUND TO THYROID RESPONSE ELEMENT DNA

Contents

Overview

Nuclear receptor heterodimers recognize response elements composed of two, direct repeats of the consensus sequence 5'-AGGTCA-3' separated by one to, five base pairs. The 1.9 A crystal structure of the complex formed by the, DNA-binding domains of the 9-cis retinoic acid receptor and thyroid, hormone receptor bound to a thyroid-response element shows that the, subunits interact through a DNA-supported interface involving the, carboxy-terminal extension of the DNA-binding domain of the thyroid, hormone receptor. The stereochemistry suggests a mechanism by which, heterodimers recognize the inter-half-site spacing between direct repeats.

Disease

Known diseases associated with this structure: Thyroid hormone resistance OMIM:[190160], Thyroid hormone resistance, autosomal recessive OMIM:[190160]

About this Structure

2NLL is a Protein complex structure of sequences from Homo sapiens with ZN as ligand. Full crystallographic information is available from OCA.

Reference

Structural determinants of nuclear receptor assembly on DNA direct repeats., Rastinejad F, Perlmann T, Evans RM, Sigler PB, Nature. 1995 May 18;375(6528):203-11. PMID:7746322

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