2no3

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Image:2no3.gif

2no3, resolution 3.20Å

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Novel 4-anilinopyrimidines as potent JNK1 Inhibitors

Contents

Overview

A new series of 4-anilinopyrimidines has been synthesized and evaluated as, JNK1 inhibitors. SAR studies led to the discovery of potent JNK1, inhibitors with good enzymatic activity as well as cellular potency, represented by compound 2b. Kinase selectivity profile and the crystal, structure of 2b are also described.

Disease

Known disease associated with this structure: Diabetes mellitus, noninsulin-dependent OMIM:[604641]

About this Structure

2NO3 is a Single protein structure of sequence from Homo sapiens with SO4 and 859 as ligands. Active as Mitogen-activated protein kinase, with EC number 2.7.11.24 Full crystallographic information is available from OCA.

Reference

Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies., Liu M, Wang S, Clampit JE, Gum RJ, Haasch DL, Rondinone CM, Trevillyan JM, Abad-Zapatero C, Fry EH, Sham HL, Liu G, Bioorg Med Chem Lett. 2007 Feb 1;17(3):668-72. Epub 2006 Nov 2. PMID:17107797

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