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1y1a
From Proteopedia
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CRYSTAL STRUCTURE OF CALCIUM AND INTEGRIN BINDING PROTEIN
Overview
Calcium- and integrin-binding protein 1 (CIB1) is involved in the process, of platelet aggregation by binding the cytoplasmic tail of the alpha(IIb), subunit of the platelet-specific integrin alpha(Iib)beta(3). Although, poorly understood, it is widely believed that CIB1 acts as a global, signaling regulator because it is expressed in many tissues that do not, express integrin alpha(Iib)beta(3). We report the structure of human CIB1, to a resolution of 2.3 A, crystallized as a dimer. The dimer interface, includes an extensive hydrophobic patch in a crystal form with 80% solvent, content. Although the dimer form of CIB1 may not be physiologically, relevant, this intersub-unit surface is likely to be linked to alpha(IIb), binding and to the binding of other signaling partner proteins. The, ... [(full description)]
About this Structure
1Y1A is a [Single protein] structure of sequence from [Homo sapiens] with CA and GSH as [ligands]. Full crystallographic information is available from [OCA].
Reference
The crystal structure of calcium- and integrin-binding protein 1: insights into redox regulated functions., Blamey CJ, Ceccarelli C, Naik UP, Bahnson BJ, Protein Sci. 2005 May;14(5):1214-21. PMID:15840829
Page seeded by OCA on Mon Oct 29 19:02:53 2007
Categories: Homo sapiens | Single protein | Bahnson, B.J. | Blamey, C.J. | Ceccarelli, C. | Naik, U.P. | CA | GSH | Calcium | Calcium-binding protein | Ef-hand | Glutathiolation | Glutathione | Integrin
