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2gfp
From Proteopedia
Structure of the Multidrug Transporter EmrD from Escherichia coli
Overview
EmrD is a multidrug transporter from the Major Facilitator Superfamily that expels amphipathic compounds across the inner membrane of Escherichia coli. Here, we report the x-ray structure of EmrD determined to a resolution of 3.5 angstroms. The structure reveals an interior that is composed mostly of hydrophobic residues, which is consistent with its role transporting amphipathic molecules. Two long loops extend into the inner leaflet side of the cell membrane. This region can serve to recognize and bind substrate directly from the lipid bilayer. We propose that multisubstrate specificity, binding, and transport are facilitated by these loop regions and the internal cavity.
About this Structure
2GFP is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
Structure of the multidrug transporter EmrD from Escherichia coli., Yin Y, He X, Szewczyk P, Nguyen T, Chang G, Science. 2006 May 5;312(5774):741-4. PMID:16675700 Page seeded by OCA on Sun May 4 05:03:12 2008
