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2obj
From Proteopedia
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Crystal structure of human PIM-1 Kinase in complex with inhibitor
Overview
A novel series of highly potent substituted pyridone Pim-1 kinase, inhibitors is described. Structural requirements for in vitro activity are, outlined as well as a complex crystal structure with the most potent Pim-1, inhibitor reported (IC(50)=50nM). A hydrogen bond matrix involving the, Pim-1 inhibitor, two water molecules, and the catalytic core, together, with a potential weak hydrogen bond between an aromatic hydrogen on the, R(1) phenyl ring and a main-chain carbonyl of Pim-1, accounts for the, overall potency of this inhibitor.
About this Structure
2OBJ is a Single protein structure of sequence from Homo sapiens with VRV as ligand. Active as Non-specific serine/threonine protein kinase, with EC number 2.7.11.1 Full crystallographic information is available from OCA.
Reference
Identification and structure-activity relationships of substituted pyridones as inhibitors of Pim-1 kinase., Cheney IW, Yan S, Appleby T, Walker H, Vo T, Yao N, Hamatake R, Hong Z, Wu JZ, Bioorg Med Chem Lett. 2007 Mar 15;17(6):1679-83. Epub 2007 Jan 4. PMID:17251021
Page seeded by OCA on Mon Nov 12 23:08:46 2007
