2uwq
From Proteopedia
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SOLUTION STRUCTURE OF ASPP2 N-TERMINUS
Overview
Proteins of the ASPP family bind to p53 and regulate p53-mediated, apoptosis. Two family members, ASPP1 and ASPP2, have pro-apoptotic, functions while iASPP shows anti-apoptotic responses. However, both the, mechanism of enhancement/repression of apoptosis and the molecular basis, for their different responses remain unknown. To address the role of the, N-termini of pro-apoptotic ASPP proteins, we solved the solution structure, of N-ASPP2 (1-83) by NMR spectroscopy. The structure of this domain, reveals a beta-Grasp ubiquitin-like fold. Our findings suggest a possible, role for the N-termini of ASPP proteins in binding to other proteins in, the apoptotic response network and thus mediating their selective, pro-apoptotic function.
About this Structure
2UWQ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Solution Structure of ASPP2 N-terminal Domain (N-ASPP2) Reveals a Ubiquitin-like Fold., Tidow H, Andreeva A, Rutherford TJ, Fersht AR, J Mol Biol. 2007 Aug 24;371(4):948-58. Epub 2007 May 13. PMID:17594908
Page seeded by OCA on Mon Nov 12 23:40:07 2007
